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KMID : 0370219860300020096
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Yakhak Hoeji
1986 Volume.30 No. 2 p.96 ~ p.99
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A Study on the Absorption Enhancing Effect of Sodium 5-Methoxysalicylate(II) -On the Activity of the Absorption Enhancing Agent-
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김기헌/Kim KH
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Abstract
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Absorption enhancing effect of 5MSA-Na at the mucous membranes of the rectum and duodenum was studied via in vitro sac test. There were no significant differences between two membranes. Effect of 5MSA-Na on the transfer of CMZ to the tissue was also studied via in situ loop method. There was no significant difference at the duodenum, compared to the control when CMZ was administered intravenously. Transfer of CMZ to the loop of the rectum was increased in the presence of 5MSA-Na compared to the control, which might be attributed to the enhanced permeability of the mucous membrane of the rectum.
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